反应详情

To a solution of the compound obtained in Example 32 (0.5 g) in 5 ml of ethanol 95° there is added potassium hydroxide (107 mg) dissolved in 1 ml of ethanol 95°. The reaction mixture is heated at reflux overnight. After cooling to ambient temperature, the solution is acidified using 1N HCl. The precipitate obtained is then filtered and purified on a reverse phase, RP18, eluant MeOH/H2O 6/4, to yield the title compound in the form of a white powder.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux overnight
3. customThe precipitate obtained
4. filtrationis then filtered
5. custompurified on a reverse phase, RP18, eluant MeOH/H2O 6/4