Hydrochloric Acid → HCID 73415001, compound

HRID 1790267Notes

Reaction equation

HRID 1790267 reaction equation
[OH:1][N:2]=[C:3]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:4]1[CH:31]=[CH:30][C:7]2[N:8]([CH2:12][CH2:13][O:14][C:15]3[CH:29]=[CH:28][C:18]([O:19][C:20]([CH3:27])([CH3:26])[C:21]([O:23]CC)=[O:22])=[CH:17][CH:16]=3)[C:9](=[O:11])[S:10][C:6]=2[CH:5]=1.[OH-].[K+].Cl>C(O)C>[OH:1][N:2]=[C:3]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:4]1[CH:31]=[CH:30][C:7]2[N:8]([CH2:12][CH2:13][O:14][C:15]3[CH:29]=[CH:28][C:18]([O:19][C:20]([CH3:27])([CH3:26])[C:21]([OH:23])=[O:22])=[CH:17][CH:16]=3)[C:9](=[O:11])[S:10][C:6]=2[CH:5]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 86596384Ethyl 2-{4-[2-(6 [(hydroxyimino)(phenyl)methyl]-2-oxo-1,3-benzo-thiazol-3(2H)-yl)ethoxy]phenoxy}-2-methylpropanoate

Product 1

HCID 73415001HCID 73415001, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of the compound obtained in Example 32 (0.5 g) in 5 ml of ethanol 95° there is added potassium hydroxide (107 mg) dissolved in 1 ml of ethanol 95°. The reaction mixture is heated at reflux overnight. After cooling to ambient temperature, the solution is acidified using 1N HCl. The precipitate obtained is then filtered and purified on a reverse phase, RP18, eluant MeOH/H2O 6/4, to yield the title compound in the form of a white powder.

Workup

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux overnight
  3. customThe precipitate obtained
  4. filtrationis then filtered
  5. custompurified on a reverse phase, RP18, eluant MeOH/H2O 6/4

Sources & evidence

ORD record
ord-5476e58a4d654c8d9d6fe2c2dbb09b99
Source dataset
uspto-grants-2006_07
Patent number
US07071221B2

Reaction notes

Loading…