Glyoxylic Acid → HCID 69585759, compound

HRID 1790281Notes

Reaction equation

HRID 1790281 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:14])[C:5]1[CH:10]=[C:9]([NH:11][NH2:12])[CH:8]=[CH:7][C:6]=1[Cl:13].O=[CH:16][C:17]([OH:19])=[O:18]>Cl>[CH3:2][O:3][C:4](=[O:14])[C:5]1[CH:10]=[C:9]([NH:11][N:12]=[CH:16][C:17]([OH:19])=[O:18])[CH:8]=[CH:7][C:6]=1[Cl:13]

Participants

4

Reactant 2

HCID 760Glyoxylic AcidHCID 69585623HCID 69585623, compound

Product 1

HCID 69585759HCID 69585759, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-Chloro-5-hydrazino-benzoic acid methyl ester hydrochloride salt (2.0 g, 8.5 mmol) and oxoacetic acid (1.0 g, 10 mmol) were taken up in 10% HCl and stirred at ambient temperature for 1.5 hours. The resulting orange precipitate was collected by filtration. The filter cake was taken up in EtOAc, washed with brine, and dried over sodium sulfate. Concentration in vacuo yielded the above named compound (1.2 g).

Workup

  1. filtrationThe resulting orange precipitate was collected by filtration
  2. washwashed with brine
  3. dry with materialdried over sodium sulfate
  4. concentrationConcentration in vacuo
  5. customyielded the

Sources & evidence

ORD record
ord-a6440d65e9064d14ad3fc361a82b8d96
Source dataset
uspto-grants-2006_07
Patent number
US07071223B1

Reaction notes

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