Diethyl Ether → 3-Pyridineethanol,6-methoxy-(9CI)

HRID 1790382Notes

Reaction equation

HRID 1790382 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.[CH2:10]([O:12]CC)[CH3:11]>>[CH3:9][O:8][C:5]1[CH:4]=[CH:3][C:2]([CH2:11][CH2:10][OH:12])=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 3283Diethyl EtherHCID 27348955-Bromo-2-methoxypyridine

Product 1

HCID 220383673-Pyridineethanol,6-methoxy-(9CI)Yield 62.7%

Procedure

5-Bromo-2-methoxypyridine (2.628 g) synthesized as reported in Tetrahedron, 1373 (1985). was dissolved in diethyl ether (40 ml) and then treated as in the above Production Example 16-1 to give the title compound (1.342 g) as a pale yellow oil (yield: 62.7%).

Workup

  1. additiontreated as in the above Production Example 16-1

Sources & evidence

ORD record
ord-2f1de5f6f73f47e19d07246a745e2b19
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

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