Acetonitrile → 1-Acetyl-6-aminoindoline

Under ice cooling, acetyl chloride (1.7 ml) was added dropwise into a solution of 1-[1-(4-t-butoxycarbonyl)piperidin-4-yl]-6-aminomethylindoline (8.3 g) and triethylamine (2.4 g) in acetonitrile (150 ml) followed by stirring the resultant mixture at room temperature for 1 hr. To the liquid reaction mixture were added a saturated aqueous solution of sodium bicarbonate and ethyl acetate and the layers were separated. The organic layer was then washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. After adding chloroform (100 ml) and trifluoroacetic acid (50 ml), the resultant mixture was stirred at room temperature for 2 hr. After concentrating under reduced pressure, a 2 N aqueous solution of sodium hydroxide (100 ml) and toluene (50 ml) were added thereto followed by vigorous stirring. Then the resultant mixture was purified by NH-silica gel column chromatography (methanol/ethyl acetate system) to give the title compound (3.78 g) as white needles (yield: 58%).

1. customTo the liquid reaction mixture
2. customthe layers were separated
3. washThe organic layer was then washed with brine
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. additionAfter adding chloroform (100 ml) and trifluoroacetic acid (50 ml)
7. concentrationAfter concentrating under reduced pressure
8. additiona 2 N aqueous solution of sodium hydroxide (100 ml) and toluene (50 ml) were added
9. customThen the resultant mixture was purified by NH-silica gel column chromatography (methanol/ethyl acetate system)

ORD record

ord-fd3a79c807b24a9bac9ef75d5fd516a0

Source dataset

uspto-grants-2006_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07071201B2