Methanesulfonyl chloride → 1-[1-(4-Methanesulfonylaminomethylphenethyl)piperidin-4-yl]indoline

HRID 1790412Notes

Reaction equation

[NH2:1][CH2:2][C:3]1[CH:25]=[CH:24][C:6]([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([N:15]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>>[CH3:26][S:27]([NH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([N:15]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)[CH2:11][CH2:10]2)=[CH:24][CH:25]=1)(=[O:29])=[O:28]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 220382211-[1-(4-Aminomethylphenethyl)piperidin-4-yl]indoline

Product 1

HCID 220380491-[1-(4-Methanesulfonylaminomethylphenethyl)piperidin-4-yl]indolineYield 54.5%

Procedure

1-[1-(4-Aminomethylphenethyl)piperidin-4-yl]indoline (0.120 g) and methanesulfonyl chloride (0.030 ml) were treated as in Example 36 to give the title compound (0.078 g) as a pale yel low oil (yield: 54.5%).

Sources & evidence

ORD record: ord-61788ba822c24d7a88900203c3ff9301
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07071201B2

Reaction notes

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