3-(4-Fluorobenzoyl)propyl chloride → 1-{1-[4-(4-Fluorophenyl)-4-oxobutyl]piperidin-4-yl}indoline

HRID 1790421Notes

Reaction equation

HRID 1790421 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.Cl[CH2:17][CH2:18][CH2:19][C:20]([C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)=[O:21]>>[F:28][C:25]1[CH:24]=[CH:23][C:22]([C:20](=[O:21])[CH2:19][CH2:18][CH2:17][N:1]2[CH2:6][CH2:5][CH:4]([N:7]3[C:15]4[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=4)[CH2:9][CH2:8]3)[CH2:3][CH2:2]2)=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 197503-(4-Fluorobenzoyl)propyl chlorideHCID 220286031-Piperidin-4-yl-2,3-dihydro-1H-indole

Product 1

HCID 220380001-{1-[4-(4-Fluorophenyl)-4-oxobutyl]piperidin-4-yl}indolineYield 27.6%

Procedure

1-(Piperidin-4-yl)indoline (1.0 g) and 4-chloro-1-(4-fluorophenyl)-1-butanone (1.1 g) were treated as in Example 2 to give the title compound (0.5 g) (yield: 27%).

Sources & evidence

ORD record
ord-3c49fb2daed44571ab4925b6595dac42
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

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