HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Fluorobenzoyl)propyl chloride → 1-{1-[4-(4-Fluorophenyl)-4-oxobutyl]piperidin-4-yl}indoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Fluorobenzoyl)propyl chloride | HCID 19750 | — |
| Reactant | 1-Piperidin-4-yl-2,3-dihydro-1H-indole | HCID 22028603 | — |
| Product | 1-{1-[4-(4-Fluorophenyl)-4-oxobutyl]piperidin-4-yl}indoline | HCID 22038000 | 27.6% |
Reaction Steps
1-(Piperidin-4-yl)indoline (1.0 g) and 4-chloro-1-(4-fluorophenyl)-1-butanone (1.1 g) were treated as in Example 2 to give the title compound (0.5 g) (yield: 27%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071201B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-3c49fb2daed44571ab4925b6595dac42 |
| Source note | uspto-grants-2006_07 |