1-(2-Bromoethyl)-4-methoxybenzene → 1-[1-(4-Methoxyphenethyl)piperidin-4-yl]-6-acetamidomethylindoline

HRID 1790433Notes

Reaction equation

HRID 1790433 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([CH2:16][NH:17][C:18](=[O:20])[CH3:19])[CH:14]=3)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[CH3:21][O:22][C:23]1[CH:31]=[CH:30][C:26]([CH2:27][CH2:28]Br)=[CH:25][CH:24]=1>>[CH3:21][O:22][C:23]1[CH:31]=[CH:30][C:26]([CH2:27][CH2:28][N:1]2[CH2:2][CH2:3][CH:4]([N:7]3[C:15]4[C:10](=[CH:11][CH:12]=[C:13]([CH2:16][NH:17][C:18](=[O:20])[CH3:19])[CH:14]=4)[CH2:9][CH2:8]3)[CH2:5][CH2:6]2)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 844271-(2-Bromoethyl)-4-methoxybenzeneHCID 220382751-(Piperidin-4-yl)-6-acetamidomethylindoline

Product 1

HCID 220381601-[1-(4-Methoxyphenethyl)piperidin-4-yl]-6-acetamidomethylindolineYield 53.7%

Procedure

1-(Piperidin-4-yl)-6-acetamidomethylindoline (250 mg) and 4-methoxyphenethyl bromide (240 mg) were treated as in Example 2 to give the title compound (200 mg) as a white powder (yield: 53%).

Sources & evidence

ORD record
ord-cfd9ed927294493280549e069f5a78b4
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

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