1-(2-Bromoethyl)-4-chlorobenzene → 1-[1-(4-Chlorophenethyl)piperidin-4-yl]-6-acetamidomethylindoline

HRID 1790434Notes

Reaction equation

HRID 1790434 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([CH2:16][NH:17][C:18](=[O:20])[CH3:19])[CH:14]=3)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[Cl:21][C:22]1[CH:30]=[CH:29][C:25]([CH2:26][CH2:27]Br)=[CH:24][CH:23]=1>>[Cl:21][C:22]1[CH:30]=[CH:29][C:25]([CH2:26][CH2:27][N:1]2[CH2:2][CH2:3][CH:4]([N:7]3[C:15]4[C:10](=[CH:11][CH:12]=[C:13]([CH2:16][NH:17][C:18](=[O:20])[CH3:19])[CH:14]=4)[CH2:9][CH2:8]3)[CH2:5][CH2:6]2)=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 230291-(2-Bromoethyl)-4-chlorobenzeneHCID 220382751-(Piperidin-4-yl)-6-acetamidomethylindoline

Product 1

HCID 220379141-[1-(4-Chlorophenethyl)piperidin-4-yl]-6-acetamidomethylindolineYield 63.7%

Procedure

1-(Piperidin-4-yl)-6-acetamidomethylindoline (250 mg) and 4-chlorophenethyl bromide (240 mg) were treated as in Example 2 to give the title compound (240 mg) as white scaly crystals (yield: 63%).

Sources & evidence

ORD record
ord-2572e495efd94b7a846d1b4132a3a55c
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

Loading…