1-(2-Bromoethyl)-3-fluorobenzene → 1-[1-(3-Fluorophenethyl)piperdin-4-yl]-6-acetamidomethylindoline

HRID 1790451Notes

Reaction equation

HRID 1790451 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([CH2:16][NH:17][C:18](=[O:20])[CH3:19])[CH:14]=3)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[F:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[CH2:25][CH2:26]Br>>[F:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[CH2:25][CH2:26][N:1]1[CH2:2][CH2:3][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([CH2:16][NH:17][C:18](=[O:20])[CH3:19])[CH:14]=3)[CH2:9][CH2:8]2)[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 5731291-(2-Bromoethyl)-3-fluorobenzeneHCID 220382751-(Piperidin-4-yl)-6-acetamidomethylindoline

Product 1

HCID 220379321-[1-(3-Fluorophenethyl)piperdin-4-yl]-6-acetamidomethylindolineYield 58.1%

Procedure

1-(Piperidin-4-yl)-6-acetamidomethylindoline (250 mg) and 3-fluorophenethyl bromide (220 mg) were treated as in Example 2 to give the title compound (210 mg) as white needles (yield: 58%).

Sources & evidence

ORD record
ord-838fbd70a9434ecf819bd5f2549b97b6
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

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