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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1790451Generated: October 31, 2026

1-(2-Bromoethyl)-3-fluorobenzene → 1-[1-(3-Fluorophenethyl)piperdin-4-yl]-6-acetamidomethylindoline

https://huagongshe.com/reaction/1790451

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Bromoethyl)-3-fluorobenzeneHCID 573129—
Reactant1-(Piperidin-4-yl)-6-acetamidomethylindolineHCID 22038275—
Product1-[1-(3-Fluorophenethyl)piperdin-4-yl]-6-acetamidomethylindolineHCID 2203793258.1%

Reaction Steps

1-(Piperidin-4-yl)-6-acetamidomethylindoline (250 mg) and 3-fluorophenethyl bromide (220 mg) were treated as in Example 2 to give the title compound (210 mg) as white needles (yield: 58%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07071201B2
Source datasetuspto-grants-2006_07
ORD IDord-838fbd70a9434ecf819bd5f2549b97b6
Source noteuspto-grants-2006_07