HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyryl chloride → 1-[1-(4-Fluorophenethyl)-piperidin-4-yl]-6-isobutyrylaminomethylindoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyryl chloride | HCID 62325 | — |
| Reactant | 1-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-aminomethylindoline | HCID 22038035 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-[1-(4-Fluorophenethyl)-piperidin-4-yl]-6-isobutyrylaminomethylindoline | HCID 22038021 | 58% |
Reaction Steps
1-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-aminomethylindoline (300 mg), triethylamine (80 mg) and isobutyryl chloride (90 mg) were treated as in Example 133 to give the title compound (200 mg) as white needles (yield: 58%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071201B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-e3387712dca3470db68e1f996fb9dfaf |
| Source note | uspto-grants-2006_07 |