Isobutyryl chloride → 1-[1-(4-Fluorophenethyl)-piperidin-4-yl]-6-isobutyrylaminomethylindoline

HRID 1790461Notes

Reaction equation

HRID 1790461 reaction equation
[F:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][CH:11]([N:14]3[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([CH2:23][NH2:24])[CH:21]=4)[CH2:16][CH2:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[C:27](Cl)(=[O:31])[CH:28]([CH3:30])[CH3:29]>C(N(CC)CC)C>[F:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][CH2:7][N:8]2[CH2:9][CH2:10][CH:11]([N:14]3[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([CH2:23][NH:24][C:27](=[O:31])[CH:28]([CH3:30])[CH3:29])[CH:21]=4)[CH2:16][CH2:15]3)[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 62325Isobutyryl chlorideHCID 220380351-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-aminomethylindoline

Product 1

HCID 220380211-[1-(4-Fluorophenethyl)-piperidin-4-yl]-6-isobutyrylaminomethylindolineYield 58%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

1-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-aminomethylindoline (300 mg), triethylamine (80 mg) and isobutyryl chloride (90 mg) were treated as in Example 133 to give the title compound (200 mg) as white needles (yield: 58%).

Sources & evidence

ORD record
ord-e3387712dca3470db68e1f996fb9dfaf
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

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