3-Bromopyridine → HCID 22038009, compound

HRID 1790466Notes

Reaction equation

HRID 1790466 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[F:8][C:9]1[CH:33]=[CH:32][C:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([N:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([CH:30]=[O:31])[CH:28]=4)[CH2:23][CH2:22]3)[CH2:17][CH2:16]2)=[CH:11][CH:10]=1>C(OCC)C>[F:8][C:9]1[CH:33]=[CH:32][C:12]([CH2:13][CH2:14][N:15]2[CH2:16][CH2:17][CH:18]([N:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([CH:30]([OH:31])[C:2]5[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=5)[CH:28]=4)[CH2:23][CH2:22]3)[CH2:19][CH2:20]2)=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 122863-BromopyridineHCID 220380721-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-formylindoline

Product 1

HCID 22038009HCID 22038009, compoundYield 68.8%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

3-Bromopyridine (0.44 ml), 1-[1-(4-fluorophenethyl)-piperidin-4-yl]-6-formylindoline (0.4 g) and diethyl ether employed as the solvent were treated as in Example 93 to give the title compound (0.337 g) as a yellow oil (yield: 68.8%).

Workup

  1. additionwere treated as in Example 93

Sources & evidence

ORD record
ord-4682ae589ccb4eb28364b61a4dd24c1e
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

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