2-Methoxypyridine → HCID 22038102, compound

HRID 1790467Notes

Reaction equation

HRID 1790467 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1.[F:9][C:10]1[CH:34]=[CH:33][C:13]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH:19]([N:22]3[C:30]4[C:25](=[CH:26][CH:27]=[C:28]([CH:31]=[O:32])[CH:29]=4)[CH2:24][CH2:23]3)[CH2:18][CH2:17]2)=[CH:12][CH:11]=1>>[F:9][C:10]1[CH:34]=[CH:33][C:13]([CH2:14][CH2:15][N:16]2[CH2:17][CH2:18][CH:19]([N:22]3[C:30]4[C:25](=[CH:26][CH:27]=[C:28]([CH:31]([OH:32])[C:8]5[C:3]([O:2][CH3:1])=[N:4][CH:5]=[CH:6][CH:7]=5)[CH:29]=4)[CH2:24][CH2:23]3)[CH2:20][CH2:21]2)=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 742012-MethoxypyridineHCID 220380721-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-formylindoline

Product 1

HCID 22038102HCID 22038102, compoundYield 75.2%

Procedure

2-Methoxypyridine (0.3 ml) and 1-[1-(4-fluorophenethyl)piperidin-4-yl]-6-formylindoline (0.5 g) were treated in accordance with the method described in J. Org. Chem., 1367 (1988). to give the title compound (0.493 g) as a pale yellow oil (yield: 75.2%).

Sources & evidence

ORD record
ord-97473d1fff47429d99067411170032d9
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

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