HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydantoin → 1-[1-(4-Fluorophenethyl)-piperdin-4-yl]-6-(2,4-imidazolidinedion-3-yl)methylindoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydantoin | HCID 10006 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-chloromethylindoline | HCID 22038253 | — |
| Product | 1-[1-(4-Fluorophenethyl)-piperdin-4-yl]-6-(2,4-imidazolidinedion-3-yl)methylindoline | HCID 22038074 | 49.1% |
Reaction Steps
Hydantoin (130 mg), 60% sodium hydride (54 mg) and 1-[1-(4-fluorophenethyl)piperidin-4-yl]-6-chloromethylindoline (400 mg) were treated as in Example 202 to give the title compound (230 mg) as a white powder (yield: 49%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071201B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-e9bfa336a970403eaf09ba797c0f7e1b |
| Source note | uspto-grants-2006_07 |