HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-[1-(4-Fluorophenethyl)-piperdin-4-yl]-3-methylindoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Methylindoline | HCID 524504 | — |
| Reactant | 1-[2-(4-Fluorophenyl)ethyl]piperidin-4-one | HCID 7023594 | — |
| Product | 1-[1-(4-Fluorophenethyl)-piperdin-4-yl]-3-methylindoline | HCID 22038358 | 75.6% |
Reaction Steps
3-Methylindoline (0.2 g) and 1-(4-fluorophenethyl)-4-piperidone (0.50 g) were treated as in Example 16 to give the title compound (0.384 g) as a pale yellow oil (yield: 7.0.7%) Next, hydrochloric acid was added thereto to give a salt followed by recrystallization from ethanol. Thus the hydrochloride (0.314 g) of the title compound was obtained as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071201B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-65edfb8f85c34bfaa4e7a6c19e94c753 |
| Source note | uspto-grants-2006_07 |