Hydrochloric Acid → 1-[1-(4-Fluorophenethyl)-piperdin-4-yl]-3-methylindoline

HRID 1790473Notes

Reaction equation

HRID 1790473 reaction equation
[CH3:1][CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][CH2:3]1.[F:11][C:12]1[CH:26]=[CH:25][C:15]([CH2:16][CH2:17][N:18]2[CH2:23][CH2:22][C:21](=O)[CH2:20][CH2:19]2)=[CH:14][CH:13]=1.Cl>>[F:11][C:12]1[CH:13]=[CH:14][C:15]([CH2:16][CH2:17][N:18]2[CH2:23][CH2:22][CH:21]([N:4]3[C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[CH:2]([CH3:1])[CH2:3]3)[CH2:20][CH2:19]2)=[CH:25][CH:26]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 5245043-MethylindolineHCID 70235941-[2-(4-Fluorophenyl)ethyl]piperidin-4-one

Product 1

HCID 220383581-[1-(4-Fluorophenethyl)-piperdin-4-yl]-3-methylindolineYield 75.6%

Procedure

3-Methylindoline (0.2 g) and 1-(4-fluorophenethyl)-4-piperidone (0.50 g) were treated as in Example 16 to give the title compound (0.384 g) as a pale yellow oil (yield: 7.0.7%) Next, hydrochloric acid was added thereto to give a salt followed by recrystallization from ethanol. Thus the hydrochloride (0.314 g) of the title compound was obtained as colorless crystals.

Sources & evidence

ORD record
ord-65edfb8f85c34bfaa4e7a6c19e94c753
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

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