4-(2-Bromoethyl)benzenesulfonamide → 1-[1-(4-Sulfamoylphenethyl)-piperdin-4-yl]-6-methoxyindoline

HRID 1790477Notes

Reaction equation

HRID 1790477 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH3:17])[CH:14]=3)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[S:18]([C:22]1[CH:30]=[CH:29][C:25]([CH2:26][CH2:27]Br)=[CH:24][CH:23]=1)(=[O:21])(=[O:20])[NH2:19]>>[S:18]([C:22]1[CH:30]=[CH:29][C:25]([CH2:26][CH2:27][N:1]2[CH2:6][CH2:5][CH:4]([N:7]3[C:15]4[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH3:17])[CH:14]=4)[CH2:9][CH2:8]3)[CH2:3][CH2:2]2)=[CH:24][CH:23]=1)(=[O:20])(=[O:21])[NH2:19]

Participants

3

Reactant 2

HCID 144850914-(2-Bromoethyl)benzenesulfonamideHCID 220381801-(Piperidin-4-yl)-6-methoxyindoline

Product 1

HCID 220382151-[1-(4-Sulfamoylphenethyl)-piperdin-4-yl]-6-methoxyindolineYield 13.1%

Procedure

1-(Piperidin-4-yl)-6-methoxyindoline (350 mg) and 4-sulfamoylphenethyl bromide (340 mg) were treated as in Example 2 to give the title compound (70 mg) as a brown powder (yield: 13%).

Sources & evidence

ORD record
ord-13a1790e7fce45129ffc70eafaf88007
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

Loading…