1-(Piperidin-4-yl)-6-methoxyindoline → 1-{1-[2-(6-Benzothiazolyl)ethyl]-piperdin-4-yl}-6-methoxyindoline

HRID 1790479Notes

Reaction equation

HRID 1790479 reaction equation
Br[CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][C:7]2[N:8]=[CH:9][S:10][C:6]=2[CH:5]=1.[NH:13]1[CH2:18][CH2:17][CH:16]([N:19]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([O:28][CH3:29])[CH:26]=3)[CH2:21][CH2:20]2)[CH2:15][CH2:14]1>>[S:10]1[C:6]2[CH:5]=[C:4]([CH2:3][CH2:2][N:13]3[CH2:18][CH2:17][CH:16]([N:19]4[C:27]5[C:22](=[CH:23][CH:24]=[C:25]([O:28][CH3:29])[CH:26]=5)[CH2:21][CH2:20]4)[CH2:15][CH2:14]3)[CH:12]=[CH:11][C:7]=2[N:8]=[CH:9]1

Participants

3

Reactant 2

HCID 220381801-(Piperidin-4-yl)-6-methoxyindolineHCID 220382056-(2-Bromoethyl)benzothiazole

Product 1

HCID 220382121-{1-[2-(6-Benzothiazolyl)ethyl]-piperdin-4-yl}-6-methoxyindolineYield 82.6%

Procedure

6-(2-Bromoethyl)benzothiazole (0.108 g) and 1-(piperidin-4-yl)-6-methoxyindoline (0.105 g) were treated as in Example 2 to give the title compound (0.145 g) as a yellow oil (yield: 81.9%).

Sources & evidence

ORD record
ord-0d67a982b1734e37aa2e5417fc75c48c
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

Loading…