反应详情

5,6,7,8-Tetrahydroisoquinoline (10 g) was added to methylene chloride (100 ml) and a 10% aqueous solution (100 ml) of sodium carbonate. Under vigorous stirring, a 70% solution of m-chloroperbenzoic acid (20 g) in methylene chloride (100 ml) was dropped thereinto at 0° C. Then the reaction solution was extracted with methylene chloride. The methylene chloride layer was washed with brine, dried and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (methylene chloride/methanol system) to give the title compound (7.50 g) as a colorless oil. (283-2) 5,6,7,8-Tetrahydroisoquinolin-5-ol

1. customat 0° C
2. extractionThen the reaction solution was extracted with methylene chloride
3. washThe methylene chloride layer was washed with brine
4. customdried
5. concentrationconcentrated under reduced pressure
6. customThe resulting residue was purified by silica gel column chromatography (methylene chloride/methanol system)