1-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-cyanoindoline → 1-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-cyanoindole

HRID 1790496Notes

Reaction equation

HRID 1790496 reaction equation
[F:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][CH:11]([N:14]3[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([C:23]#[N:24])[CH:21]=4)[CH2:16][CH2:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1>[O-2].[O-2].[Mn+4]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH2:7][N:8]2[CH2:9][CH2:10][CH:11]([N:14]3[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([C:23]#[N:24])[CH:21]=4)[CH:16]=[CH:15]3)[CH2:12][CH2:13]2)=[CH:25][CH:26]=1

Participants

3

Reactant 1

HCID 110786031-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-cyanoindoline

Product 1

HCID 220380641-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-cyanoindoleYield 84.5%

Reagents, catalysts & solvents 1

HCID 178418406HCID 178418406, compoundCatalyst

Procedure

1-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-cyanoindoline (0.50 g) obtained in Example 124 and active manganese dioxide (1.00 g) were treated as in Example 288 to give the title compound (0.42 g) as a white powder (yield: 83.8%).

Sources & evidence

ORD record
ord-6ced43dfa1b9493f945103a2c061ea56
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

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