4-Aminobenzonitrile → HCID 54413676, compound

HRID 1790533Notes

Reaction equation

HRID 1790533 reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]([O:15][CH3:16])[C:6]([O:13][CH3:14])=[C:7]([CH:12]=1)[C:8]([O:10][CH3:11])=[O:9])=O.[NH2:17][C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=1.C([N+]#[C-])C1C=CC=CC=1>>[C:22]([C:21]1[CH:24]=[CH:25][C:18]([NH:17][CH:1]([C:8]([O:10][CH3:11])=[O:9])[C:3]2[CH:4]=[C:5]([O:15][CH3:16])[C:6]([O:13][CH3:14])=[C:7]([CH:12]=2)[C:8]([O:10][CH3:11])=[O:9])=[CH:19][CH:20]=1)#[N:23]

Participants

4

Reactant 3

HCID 133964-AminobenzonitrileHCID 82558Benzyl isocyanideHCID 22040032HCID 22040032, compound

Product 1

HCID 54413676HCID 54413676, compound

Procedure

In analogy to Example 1.1, methyl 5-formyl-2,3-dimethoxy-benzoate (F. Y. Wu, D. L. b rink, J. Agric. Food Chem. (1977) 25 692) was reacted with 4-aminobenzonitrile and benzyl isonitrile to give methyl (RS)-5-[(4-cyano-phenylamino)-methoxycarbonyl-methyl]-2,3-dimethoxy-benzoate.

Sources & evidence

ORD record
ord-17bfc81018684969b5db50f881bf3c10
Source dataset
uspto-grants-2006_07
Patent number
US07071212B2

Reaction notes

Loading…