Methyl iodide → 1-(4-Tert-butyl-phenyl)-4-methyl-piperidine-4-carboxylic acid ethyl ester

HRID 179064Notes

Reaction equation

HRID 179064 reaction equation
[CH2:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1.[CH2:19]([CH3:20])[O:21][C:22](=[O:23])[CH:24]1[CH2:25][CH2:26][N:27]([c:30]2[cH:31][cH:32][c:33]([C:36]([CH3:37])([CH3:38])[CH3:39])[cH:34][cH:35]2)[CH2:28][CH2:29]1.[CH2:8]([Li:9])[CH2:10][CH2:11][CH3:12].[CH3:40][I:41].[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[O:42]1[CH2:43][CH2:44][CH2:45][CH2:46]1>>[CH3:1][C:24]1([C:22]([O:21][CH2:19][CH3:20])=[O:23])[CH2:25][CH2:26][N:27]([c:30]2[cH:31][cH:32][c:33]([C:36]([CH3:37])([CH3:38])[CH3:39])[cH:34][cH:35]2)[CH2:28][CH2:29]1

Participants

7

Reactant 6

HCID 6328Methyl iodideHCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 8078CyclohexaneHCID 58118066HCID 58118066, compoundHCID 178418339Butyllithium

Product 1

HCID 581180261-(4-Tert-butyl-phenyl)-4-methyl-piperidine-4-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-19cff5f9833a4ae18df52d52acc5972d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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