Hydrochloric Acid → HCID 68999700, compound

HRID 1790647Notes

Reaction equation

HRID 1790647 reaction equation
Cl.C(OC(=O)[NH:8][C@H:9]([C:17](=[O:31])[NH:18][C@H:19]1[CH2:25][CH2:24][C@@H:23]([CH3:26])[N:22]([CH2:27][CH2:28][CH3:29])[CH2:21][C@@H:20]1[OH:30])[CH2:10][CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)(C)(C)C>O1CCOCC1.CO>[NH2:8][C@@H:9]([CH2:10][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1)[C:17]([NH:18][C@H:19]1[CH2:25][CH2:24][C@@H:23]([CH3:26])[N:22]([CH2:27][CH2:28][CH3:29])[CH2:21][C@@H:20]1[OH:30])=[O:31]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58665050HCID 58665050, compound

Product 1

HCID 68999700HCID 68999700, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

HCl in dioxane (4.0 M, 15 ml) was added to a stirred solution of [(S)-2-Cyclohexyl-1-((3S,4S,7R)-3-hydroxy-7-methyl-1-propyl-azepan-4-ylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester (1.4 g, 3.0 mmol) in MeOH (5 ml). The reaction mixture was stirred for 2 h at RT, then was concentrated in vacuo by rotary evaporation and was used in the next reaction without further purification (1.4 g).

Workup

  1. concentrationwas concentrated in vacuo by rotary evaporation
  2. customwas used in the next reaction without further purification (1.4 g)

Sources & evidence

ORD record
ord-1d155c4ad4fa41e3814756aa377f9a0c
Source dataset
uspto-grants-2006_07
Patent number
US07071184B2

Reaction notes

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