反应详情

(2R,5R,6R)-5-tert-Butoxycarbonylamino-6-hydroxy-2-methyl-azepane-1-carboxylic acid benzyl ester (0.9 g, 2.4 mmol) was dissolved in EtOAc (40 ml), then 10% Pd/C (0.45 g) was added and the reaction mixture was degasses by bubbling argon for 5 minutes. Then, the reaction was stirred overnight under a balloon filled with hydrogen gas. The reaction mixture was filtered through Celite, concentrated in vacuo by rotary evaporation and was azeotroped with toluene (20 ml), then was used in the next reaction without further purification (0.58 g, quantitative): Electrospray mass spec: M+H+=245.2.

1. customby bubbling argon for 5 minutes
2. additionfilled with hydrogen gas
3. filtrationThe reaction mixture was filtered through Celite
4. concentrationconcentrated in vacuo by rotary evaporation
5. customwas azeotroped with toluene (20 ml)
6. customwas used in the next reaction without further purification (0.58 g, quantitative)