反应详情

温度

100 °C

A solution of 5 (1 eq), 6 (1 eq), and sodium carbonate (1.2 eq) in DME/H2O (3:1) was degassed by bubbling argon through the solution for 10 minutes. Pd(II)(dppf)Cl2.MeCl2 (0.1 eq) was added to the reaction solution and the reaction was sealed. The reaction was heated at 100° C. overnight. The reaction was cooled to RT and ethyl acetate and water were added. The organic layer was separated from the aqueous layer. The aqueous layer was washed once more with ethyl acetate. The organic layers were combined, dried (Na2SO4), and concentrated under vacuum to yield the desired product 7. MS: MH+=469

1. customby bubbling argon through the solution for 10 minutes
2. customthe reaction was sealed
3. temperatureThe reaction was cooled to RT
4. customThe organic layer was separated from the aqueous layer
5. washThe aqueous layer was washed once more with ethyl acetate
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated under vacuum