1,2-Ethanediamine, N1,N2-bis(phenylmethyl)-, acetate (1:2) → Benzathine

HRID 1790723Notes

Reaction equation

HRID 1790723 reaction equation
CC(O)=O.CC(O)=O.[CH:9]1[CH:14]=[CH:13][C:12]([CH2:15][NH:16][CH2:17][CH2:18][NH:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:11][CH:10]=1>O>[CH:9]1[CH:10]=[CH:11][C:12]([CH2:15][NH:16][CH2:17][CH2:18][NH:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 1

HCID 312281,2-Ethanediamine, N1,N2-bis(phenylmethyl)-, acetate (1:2)

Product 1

HCID 8793BenzathineYield 282.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 15.14 g of benzathine diacetate in 160 ml demineralised water was added over 15 minutes to the decolorized solution at 150 to 20° C. The mixture was agitated for 30 minutes at 15° to 20° C., cooled to 0° to +5° C. and agitated for 1 hour. The mixture was filtered and washed 3 times with 50 ml of water. It was thoroughly squeezed under a nitrogen flow to obtain 28.52 g of the benzathine salt of the condensation product of 7-ACT with COMBA. A sample was dried for analysis.

Workup

  1. additionwas added over 15 minutes to the decolorized solution at 150 to 20° C
  2. temperaturecooled to 0° to +5° C.
  3. stirringagitated for 1 hour
  4. filtrationThe mixture was filtered
  5. washwashed 3 times with 50 ml of water

Sources & evidence

ORD record
ord-1b4bf2f24b03424ebc2b70000c15ee95
Source dataset
uspto-grants-2006_07
Patent number
US07071329B2

Reaction notes

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