反应详情

A solution of benzyl-2-(N-FMOC-L-valyloxy)stearate (4.4 g, 6.2 mmole) in 50 ml ethyl acetate was hydrogenated with 10% palladium on charcoal (0.5 g) with normal pressure for two hours. The catalyst was filtered and washed with ethyl acetate and 1,4-dioxane. The solution was evaporated under reduced pressure and the product was isolated by silica gel column chromatography. Yield: 3.4 g

1. filtrationThe catalyst was filtered
2. washwashed with ethyl acetate and 1,4-dioxane
3. customThe solution was evaporated under reduced pressure
4. customthe product was isolated by silica gel column chromatography