反应详情

Lithium aluminum hydride (0.46 g, 12 mmol) was added 5-(2-morpholin-4-yl-2-oxo-ethoxy)-1H-indole-2-carboxylic acid ethyl ester (0.8 g, 2.4 mmol) in tetrahydrofuran (50 mL). The mixture was stirred at room temperature for 16 hours and cooled to 0° C. It was then quenched with water (4.6 mL), 15% sodium hydroxide (4.6 mL) and water (4.6 mL). The precipitate was filtered off and the filtrate was concentrated to give 0.7 g of [5-(2-morpholin-4-yl-ethoxy)-1H-indol-2-yl]-methanol.

1. temperaturecooled to 0° C
2. customIt was then quenched with water (4.6 mL), 15% sodium hydroxide (4.6 mL) and water (4.6 mL)
3. filtrationThe precipitate was filtered off
4. concentrationthe filtrate was concentrated