2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid (3-chlorophenyl)amide → 2-Oxo-3-[5-(2-pyrrolidin-1-yl-ethoxy)-1H-indol-2-ylmethylene]-2,3-dihydro-1H-indole-5-sulfonic acid (3-chloro-phenyl)-amide

HRID 1790948Notes

Reaction equation

HRID 1790948 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][S:9]([C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16](=[O:21])[CH2:15]3)(=[O:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.[N:22]1([CH2:27][CH2:28][O:29][C:30]2[CH:31]=[C:32]3[C:36](=[CH:37][CH:38]=2)[NH:35][C:34]([CH:39]=O)=[CH:33]3)[CH2:26][CH2:25][CH2:24][CH2:23]1>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][S:9]([C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16](=[O:21])[C:15]3=[CH:39][C:34]2[NH:35][C:36]3[C:32]([CH:33]=2)=[CH:31][C:30]([O:29][CH2:28][CH2:27][N:22]2[CH2:26][CH2:25][CH2:24][CH2:23]2)=[CH:38][CH:37]=3)(=[O:11])=[O:10])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 90558432-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid (3-chlorophenyl)amideHCID 220420925-(2-pyrrolidin-1-yl-ethoxy)-1H-indole-2-carbaldehyde

Product 1

HCID 865851062-Oxo-3-[5-(2-pyrrolidin-1-yl-ethoxy)-1H-indol-2-ylmethylene]-2,3-dihydro-1H-indole-5-sulfonic acid (3-chloro-phenyl)-amide

Procedure

2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid (3-chloro-phenyl)-amide was condensed with 5-(2-pyrrolidin-1-yl-ethoxy)-1H-indole-2-carbaldehyde to give the title compound.

Sources & evidence

ORD record
ord-f1249bb3463e43fc971683f1618fa3f1
Source dataset
uspto-grants-2006_07
Patent number
US07071332B2

Reaction notes

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