Hydrochloric Acid → HCID 131725846, compound

HRID 1791065Notes

Reaction equation

HRID 1791065 reaction equation
CC1C=CC([O:8][S:9]([C:12]2[CH:13]=[C:14]([NH:18][S:19]([C:22]3[CH:31]=[C:30]4[C:25]([CH:26]=[CH:27][C:28]([NH:32][C:33]([NH:35][C:36]5[CH:45]=[C:44]6[C:39]([CH:40]=[CH:41][C:42]([S:46]([NH:49][C:50]7[CH:51]=[C:52]([S:56]([O:59]C8C=CC(C)=CC=8)(=[O:58])=[O:57])[CH:53]=[CH:54][CH:55]=7)(=[O:48])=[O:47])=[CH:43]6)=[CH:38][CH:37]=5)=[O:34])=[CH:29]4)=[CH:24][CH:23]=3)(=[O:21])=[O:20])[CH:15]=[CH:16][CH:17]=2)(=[O:11])=[O:10])=CC=1.[OH-].[Na+:68].Cl>>[Na+:68].[Na+:68].[S:56]([C:52]1[CH:51]=[C:50]([NH:49][S:46]([C:42]2[CH:43]=[C:44]3[C:39]([CH:38]=[CH:37][C:36]([NH:35][C:33]([NH:32][C:28]4[CH:29]=[C:30]5[C:25]([CH:24]=[CH:23][C:22]([S:19]([NH:18][C:14]6[CH:13]=[C:12]([S:9]([O-:11])(=[O:8])=[O:10])[CH:17]=[CH:16][CH:15]=6)(=[O:21])=[O:20])=[CH:31]5)=[CH:26][CH:27]=4)=[O:34])=[CH:45]3)=[CH:40][CH:41]=2)(=[O:48])=[O:47])[CH:55]=[CH:54][CH:53]=1)([OH:59])(=[O:57])=[O:58].[S:56]([C:52]1[CH:51]=[C:50]([NH:49][S:46]([C:42]2[CH:43]=[C:44]3[C:39]([CH:38]=[CH:37][C:36]([NH:35][C:33]([NH:32][C:28]4[CH:29]=[C:30]5[C:25]([CH:24]=[CH:23][C:22]([S:19]([NH:18][C:14]6[CH:13]=[C:12]([S:9]([O-:11])(=[O:8])=[O:10])[CH:17]=[CH:16][CH:15]=6)(=[O:21])=[O:20])=[CH:31]5)=[CH:26][CH:27]=4)=[O:34])=[CH:45]3)=[CH:40][CH:41]=2)(=[O:48])=[O:47])[CH:55]=[CH:54][CH:53]=1)([OH:59])(=[O:57])=[O:58]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 9832945HCID 9832945, compound

Product 1

HCID 131725846HCID 131725846, compound

Procedure

To 35 mg (0.036 mmol) of compound 9 was added 2 mL of 5 N NaOH. The reaction was allowed to stir at ambient temperature for 6 hours. The reaction was acidified with 6 N HCl and the solution was added to a small reverse-phase (C18) solid phase extraction column. The column was washed with H2O followed by 50:50 (v:v) CH3CN:H2O to elute the product. This provided 26 mg of compound 13.

Workup

  1. additionthe solution was added to a small reverse-phase (C18) solid phase extraction column
  2. washThe column was washed with H2O
  3. washH2O to elute the product

Sources & evidence

ORD record
ord-d8f8941d558d487dac6430f9c8d0c26d
Source dataset
uspto-grants-2006_07
Patent number
US07071231B2

Reaction notes

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