Hydrochloric Acid → HCID 131725847, compound

HRID 1791068Notes

Reaction equation

[NH4+].[NH4+].C([O:5][C:6]([CH2:8][O:9][C:10]1[CH:19]=[C:18]([S:20]([OH:23])(=[O:22])=[O:21])[CH:17]=[C:16]2[C:11]=1[CH:12]=[CH:13][C:14]([NH:24][C:25]([NH:27][C:28]1[CH:37]=[C:36]3[C:31]([C:32]([OH:42])=[CH:33][C:34]([S:38]([O-:41])(=[O:40])=[O:39])=[CH:35]3)=[CH:30][CH:29]=1)=[O:26])=[CH:15]2)=[O:7])C.C([O:45][C:46]([CH2:48][O:49][C:50]1[CH:59]=[C:58]([S:60]([OH:63])(=[O:62])=[O:61])[CH:57]=[C:56]2[C:51]=1[CH:52]=[CH:53][C:54]([NH:64][C:65]([NH:67][C:68]1[CH:77]=[C:76]3[C:71]([C:72]([OH:82])=[CH:73][C:74]([S:78]([O-:81])(=[O:80])=[O:79])=[CH:75]3)=[CH:70][CH:69]=1)=[O:66])=[CH:55]2)=[O:47])C.[OH-].[Na+:84].Cl>>[Na+:84].[Na+:84].[OH:42][C:32]1[CH:33]=[C:34]([S:38]([OH:41])(=[O:40])=[O:39])[CH:35]=[C:36]2[C:31]=1[CH:30]=[CH:29][C:28]([NH:27][C:25]([NH:24][C:14]1[CH:15]=[C:16]3[C:11](=[CH:12][CH:13]=1)[C:10]([O:9][CH2:8][C:6]([O-:7])=[O:5])=[CH:19][C:18]([S:20]([OH:23])(=[O:22])=[O:21])=[CH:17]3)=[O:26])=[CH:37]2.[OH:82][C:72]1[CH:73]=[C:74]([S:78]([OH:81])(=[O:80])=[O:79])[CH:75]=[C:76]2[C:71]=1[CH:70]=[CH:69][C:68]([NH:67][C:65]([NH:64][C:54]1[CH:55]=[C:56]3[C:51](=[CH:52][CH:53]=1)[C:50]([O:49][CH2:48][C:46]([O-:47])=[O:45])=[CH:59][C:58]([S:60]([OH:63])(=[O:62])=[O:61])=[CH:57]3)=[O:66])=[CH:77]2

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 14798Sodium Hydroxide

HCID 131725848HCID 131725848, compound

Product 1

HCID 131725847HCID 131725847, compound

Procedure

To 25 mg (0.04 mmol) of compound 94 was added 1 mL of 5 N NaOH. The solution was allowed to stir for 18 hours at ambient temperature. The pH was lowered to 1 with aqueous HCl and the resulting solid was collected by vacuum filtration to afford 16 mg of compound 96.

Workup

filtrationthe resulting solid was collected by vacuum filtration

Sources & evidence

ORD record: ord-4cfc17a8dc7541c4a99b863a0fe071df
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07071231B2

Reaction notes

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