HCID 22041793, compound → HCID 9962545, compound

HRID 1791084Notes

Reaction equation

HRID 1791084 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([S:12]([NH:15][C:16]3[CH:17]=[CH:18][C:19]([Cl:26])=[C:20]([CH:25]=3)[C:21]([O:23][CH3:24])=[O:22])(=[O:14])=[O:13])=[CH:9]2)=[CH:4][CH:3]=1.[Cl:27][C:28]1[CH:37]=[CH:36][C:35]([NH:38][S:39]([C:42]2[CH:51]=[CH:50][C:49]3[C:44](=[CH:45][C:46]([N:52]=[C:53]=[S:54])=[CH:47][CH:48]=3)[CH:43]=2)(=[O:41])=[O:40])=[CH:34][C:29]=1[C:30]([O:32][CH3:33])=[O:31]>ClCCl>[Cl:26][C:19]1[CH:18]=[CH:17][C:16]([NH:15][S:12]([C:8]2[CH:7]=[CH:6][C:5]3[C:10](=[CH:11][C:2]([NH:1][C:53]([NH:52][C:46]4[CH:47]=[CH:48][C:49]5[C:44](=[CH:43][C:42]([S:39]([NH:38][C:35]6[CH:36]=[CH:37][C:28]([Cl:27])=[C:29]([C:30]([O:32][CH3:33])=[O:31])[CH:34]=6)(=[O:40])=[O:41])=[CH:51][CH:50]=5)[CH:45]=4)=[S:54])=[CH:3][CH:4]=3)[CH:9]=2)(=[O:14])=[O:13])=[CH:25][C:20]=1[C:21]([O:23][CH3:24])=[O:22]

Participants

4

Reactant 2

HCID 22041793HCID 22041793, compoundHCID 22041814HCID 22041814, compound

Product 1

HCID 9962545HCID 9962545, compoundYield 82.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 3.0 g (7.68 mmol) of compound 134 was added a solution of 4.0 g (9.24 mmol) of compound 135 in 200 mL of dichloromethane. The reaction was allowed to stir at ambient temperature for 48 hours. The fine, white solid was collected to give 5.2 g of compound 157.

Workup

  1. customThe fine, white solid was collected

Sources & evidence

ORD record
ord-de621f935b8f431f98196f90fe51bfa6
Source dataset
uspto-grants-2006_07
Patent number
US07071231B2

Reaction notes

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