Bicarbonate Ion → HCID 23535375, compound

HRID 1791112Notes

Reaction equation

HRID 1791112 reaction equation
[As:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([CH2:12][S:13][CH2:14][CH2:15][C:16]([NH:18][C@H:19]([C:24]([OH:26])=[O:25])[CH2:20][C:21](O)=O)=[O:17])=[O:11])=[CH:5][CH:4]=1)=[O:2].SCCC(N[C@H](C([O-])=O)CC[C:36]([O-:38])=[O:37])=O.[Na+].[Na+].C(=O)(O)[O-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>CS(C)=O>[As:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([CH2:12][S:13][CH2:14][CH2:15][C:16]([NH:18][C@H:19]([C:24]([OH:26])=[O:25])[CH2:20][CH2:21][C:36]([OH:38])=[O:37])=[O:17])=[O:11])=[CH:5][CH:4]=1)=[O:2]

Participants

6

Reactant 4

HCID 769Bicarbonate IonHCID 11776TriphenylphosphineHCID 23535373HCID 23535373, compoundHCID 86593470HCID 86593470, compound

Product 1

HCID 23535375HCID 23535375, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent3×

Procedure

The procedure used was the same as for N-(3-(4-arsenosophenylcarbamoylmethylthio)-propanoyl)-L-aspartic acid, using 2.63 mL (184 μmol) of 70.0 mM BRAO in DMSO, the disulfide of disodium N-(3-mercaptopropanoyl)-L-glutamate (0.61 g), 0.5 M bicarbonate buffer, pH 9 (10.52 mL, 5.3 mmol), and 0.69 M triphenylphosphine in DMSO (1.7 mL, 1.2 mmol). In this case, DMSO (2 mL) was added to the precipitated mixture before leaving overnight. The active concentration of trivalent arsenic was found to be 15.4 mM (10.3 mL of solution).

Workup

  1. custombefore leaving overnight
  2. concentrationThe active concentration of trivalent arsenic

Sources & evidence

ORD record
ord-7de85a4229cb46598044063bcdac42a6
Source dataset
uspto-grants-2006_07
Patent number
US07074766B1

Reaction notes

Loading…