Piperidine → HCID 10277398, compound

HRID 1791124Notes

Reaction equation

HRID 1791124 reaction equation
Br[CH2:2][C:3]1[NH:8][C:7]([C:9]2[C:14]([F:15])=[CH:13][C:12]([F:16])=[CH:11][N:10]=2)=[N:6][C@@H:5]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=2[Cl:24])[C:4]=1[C:25]([O:27][CH3:28])=[O:26].[NH:29]1[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1>CO.O>[Cl:24][C:18]1[CH:19]=[C:20]([F:23])[CH:21]=[CH:22][C:17]=1[C@H:5]1[C:4]([C:25]([O:27][CH3:28])=[O:26])=[C:3]([CH2:2][N:29]2[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)[NH:8][C:7]([C:9]2[C:14]([F:15])=[CH:13][C:12]([F:16])=[CH:11][N:10]=2)=[N:6]1

Participants

5

Reactant 2

HCID 8082PiperidineHCID 15547738HCID 15547738, compound

Product 1

HCID 10277398HCID 10277398, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of 100 mg of freshly prepared methyl (R)-6-bromomethyl-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridyl)-1,4-dihydropyrimidine-5-carboxylate from Example XIII in 0.5 ml of methanol is mixed with 5 equivalents of piperidine and stirred at room temperature for 30 minutes. The solution is diluted with water and extracted with ethyl acetate.

Workup

  1. extractionextracted with ethyl acetate

Sources & evidence

ORD record
ord-b610980781e74c28a501900471243f2b
Source dataset
uspto-grants-2006_07
Patent number
US07074784B2

Reaction notes

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