2-(2-Nitrobenzylamino)succinic acid dimethyl ester → HCID 23535553, compound

HRID 1791129Notes

Reaction equation

HRID 1791129 reaction equation
[CH3:1][O:2][C:3](=[O:21])[CH:4]([NH:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[N+:18]([O-])=O)[CH2:5][C:6]([O:8][CH3:9])=[O:7].[H][H]>CO.[Pt]=O>[CH3:1][O:2][C:3](=[O:21])[CH:4]([NH:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[NH2:18])[CH2:5][C:6]([O:8][CH3:9])=[O:7]

Participants

5

Reactant 2

HCID 235355542-(2-Nitrobenzylamino)succinic acid dimethyl esterHCID 178418361HCID 178418361, compound

Product 1

HCID 23535553HCID 23535553, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

A mixture of 2-(2-nitrobenzylamino)succinic acid dimethyl ester [from a) above] (7.6 g, 25.65 mmol) and platinum oxide (349.51 mg, 1.54 mmol) was shaken in methanol on a Parr hydrogenation apparatus under 50 psi of hydrogen gas. After 12 h the mixture was filtered and concentrated to give 6.6 g of the title compound as a light brown oil.

Workup

  1. filtrationAfter 12 h the mixture was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-23085d74e8b84ffc85b6cd273237a8e0
Source dataset
uspto-grants-2006_07
Patent number
US07074783B2

Reaction notes

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