HCID 178418361, compound → HCID 178437651, compound

HRID 1791193Notes

Reaction equation

HRID 1791193 reaction equation
[C:1]([C@@H:5]1[CH2:10][CH2:9][C@H:8]([C:11]2[N:19]3[C:14]([C:15](=[O:29])[NH:16][C:17]([C:20]4[CH:25]=[CH:24][C:23]([N+:26]([O-])=O)=[CH:22][CH:21]=4)=[N:18]3)=[C:13]([CH2:30][CH3:31])[N:12]=2)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[H][H]>O1CCCC1.[Pd]>[NH2:26][C:23]1[CH:24]=[CH:25][C:20]([C:17]2[NH:16][C:15](=[O:29])[C:14]3=[C:13]([CH2:30][CH3:31])[N:12]=[C:11]([C@H:8]4[CH2:9][CH2:10][C@@H:5]([C:1]([CH3:3])([CH3:2])[CH3:4])[CH2:6][CH2:7]4)[N:19]3[N:18]=2)=[CH:21][CH:22]=1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178437652HCID 178437652, compound

Product 1

HCID 178437651HCID 178437651, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

580 mg (1.37 mmol) cis-7-(4-tert-butylcyclohexyl)-5-ethyl-2-(4-nitrophenyl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one (Example 36A) are dissolved in 50 ml tetrahydrofuran and catalytic amounts of palladium (10% on charcoal) are added. The mixture is stirred for 18 hour at room temperature in a 3 bar hydrogen atmosphere. Then the mixture is filtrated and the organic phase evaporated to dryness in vacuo.

Workup

  1. filtrationThen the mixture is filtrated
  2. customthe organic phase evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-ca737ecba18b4b259414def625785f5c
Source dataset
uspto-grants-2006_07
Patent number
US07074790B2

Reaction notes

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