Dichloromethane → HCID 178437649, compound

HRID 1791195Notes

Reaction equation

HRID 1791195 reaction equation
[C:1]([C@@H:5]1[CH2:10][CH2:9][C@H:8]([C:11]2[N:19]3[C:14]([C:15](=[O:28])[NH:16][C:17]([C:20]4[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=4)[C:23]#[N:24])=[N:18]3)=[C:13]([CH2:29][CH3:30])[N:12]=2)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-:32].[K+].[K+].ClCCl>C(O)C.O>[C:1]([C@@H:5]1[CH2:6][CH2:7][C@H:8]([C:11]2[N:19]3[C:14]([C:15](=[O:28])[NH:16][C:17]([C:20]4[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=4)[C:23]([NH2:24])=[O:32])=[N:18]3)=[C:13]([CH2:29][CH3:30])[N:12]=2)[CH2:9][CH2:10]1)([CH3:4])([CH3:3])[CH3:2]

Participants

6

Reactant 3

HCID 6344DichloromethaneHCID 11430Potassium CarbonateHCID 178437648HCID 178437648, compound

Product 1

HCID 178437649HCID 178437649, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

100 mg (0.25 mmol) cis-3-[7-(4-tert-butylcyclohexyl)-5-ethyl-4-oxo-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl]benzonitrile (Example 40A) are dissolved in 5 ml ethanol and 10 ml water. 342 mg (2.48 mmol) potassium carbonate and 281 mg (2.48 mmol) hydrogene peroxide are added. The reaction mixture is stirred at room temperature for 18 hours. Dichloromethane is added, the organic phase separated, dried over sodium sulfate and evaporated to dryness in vacuo.

Workup

  1. customthe organic phase separated
  2. dry with materialdried over sodium sulfate
  3. customevaporated to dryness in vacuo

Sources & evidence

ORD record
ord-51044c91d0ff457886ab82df0c68c972
Source dataset
uspto-grants-2006_07
Patent number
US07074790B2

Reaction notes

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