反应详情

Heat a mixture of 7-(2-trifluoromethyl-phenyl)-quinolin-4-ol (50 mg, 0.17 mmol) in POCl3 (10 mL) at 90° C. for 16 hours. Evaporate the POCl3, and add ice (100 g) followed by careful addition of saturated NaHCO3. Extract with EtOAc, dry (Na2SO4), and evaporate to provide 4-chloro-7-(2-trifluoromethyl-phenyl)-quinoline as a tan solid.

1. temperatureHeat
2. customEvaporate the POCl3
3. additionadd ice (100 g)
4. additionfollowed by careful addition of saturated NaHCO3
5. extractionExtract with EtOAc
6. dry with materialdry (Na2SO4)
7. customevaporate