反应详情

Reflux a solution of 7-bromo-3H-quinazolin-4-one (1.24 g, 0.0055 mol) in POCl3 for 3.5 h. Remove the excess POCl3 under reduced pressure and partition the residue between EtOAc and saturated aqueous NaHCO3. Dry the EtOAc layer and remove the solvent under reduced pressure to give 7-bromo-4-chloro-quinazoline as a yellow solid.

1. customRemove the excess POCl3 under reduced pressure
2. custompartition the residue between EtOAc and saturated aqueous NaHCO3
3. dry with materialDry the EtOAc layer
4. customremove the solvent under reduced pressure