Phosphorus oxychloride → 4-Chloro-7-[3-(trifluoromethyl)-2-pyridinyl]quinazoline

HRID 1791222Notes

Reaction equation

HRID 1791222 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[C:4]([C:9]2[CH:18]=[C:17]3[C:12]([C:13](O)=[N:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)=[N:5][CH:6]=[CH:7][CH:8]=1.O=P(Cl)(Cl)[Cl:24]>>[Cl:24][C:13]1[C:12]2[C:17](=[CH:18][C:9]([C:4]3[C:3]([C:2]([F:21])([F:20])[F:1])=[CH:8][CH:7]=[CH:6][N:5]=3)=[CH:10][CH:11]=2)[N:16]=[CH:15][N:14]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178517950HCID 178517950, compound

Product 1

HCID 220303844-Chloro-7-[3-(trifluoromethyl)-2-pyridinyl]quinazoline

Procedure

Reflux 7-(3-trifluoromethyl-pyridin-2-yl)-quinazolin-4-ol (0.38 mmol) for 18 hours in POCl3 (5 mL). Evaporate the solvent in vacuo, then carefully neutralize with saturated NaHCO3, and extract with EtOAc. Dry over Na2SO4, concentrate under vacuum to obtain 4-chloro-7-(3-trifluoromethyl-pyridin-2-yl)-quinazoline.

Workup

  1. customEvaporate the solvent in vacuo
  2. extractionextract with EtOAc
  3. dry with materialDry over Na2SO4
  4. concentrationconcentrate under vacuum

Sources & evidence

ORD record
ord-59c0121a94384cc9816e0179000b2cbe
Source dataset
uspto-grants-2006_07
Patent number
US07074799B2

Reaction notes

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