HCID 22030167, compound → 2-Amino-4-[3-(trifluoromethyl)-2-pyridinyl]benzoic acid

HRID 1791230Notes

Reaction equation

HRID 1791230 reaction equation
[N+:1]([C:4]1[CH:12]=[C:11]([C:13]2[C:18]([C:19]([F:22])([F:21])[F:20])=[CH:17][CH:16]=[CH:15][N:14]=2)[CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-])=O>CCO.[Pd]>[NH2:1][C:4]1[CH:12]=[C:11]([C:13]2[C:18]([C:19]([F:22])([F:20])[F:21])=[CH:17][CH:16]=[CH:15][N:14]=2)[CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

Participants

4

Reactant 1

HCID 22030167HCID 22030167, compound

Product 1

HCID 220302532-Amino-4-[3-(trifluoromethyl)-2-pyridinyl]benzoic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Hydrogenate the solution of 2-nitro-4-(3-trifluoromethyl-pyridin-2-yl)-benzoic acid (3.84 mmol) in 95% EtOH (100 mL) with 10% Pd-C (150 mg) for over night. Filter through a celite pad and concentrate the filtrate to give 2-amino-4(3-trifluoromethyl-pyridin-2-yl)-benzoic acid.

Workup

  1. filtrationFilter through a celite pad
  2. concentrationconcentrate the filtrate

Sources & evidence

ORD record
ord-5526c94546d94210aab6ec50f967604d
Source dataset
uspto-grants-2006_07
Patent number
US07074799B2

Reaction notes

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