HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-o-cresol → 3-t-Butoxycarbonylamino-2-methylphenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-o-cresol | HCID 104448 | — |
| Reactant | Carbonic acid, bis(1,1-dimethylethyl) ester | HCID 10219638 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-t-Butoxycarbonylamino-2-methylphenol | HCID 22033487 | 69% |
Reaction Steps
3-Amino-2-methylphenol (2.0 g; 16 mmol) and di-t-butylcarbonate were dissolved in THF (20 mL) and refluxed overnight. Evaporation of the solvent followed by flash chromatography (SiO2; EtOAc 5–30% in isohexane) afforded 2.48 g (69%) of the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07074820B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-7d57a165596141cbaf972e1129adb4f6 |
| Source note | uspto-grants-2006_07 |