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HRID1791852

反应详情

EQUATION

反应方程式

HRID 1791852 的结构方程式

REACTANTS

反应物

2
结构：Cc1c(N)cccc1O
HCID104448

2-Amino-o-cresol

C7H9NO

结构：CC(C)(C)OC(=O)OC(C)(C)C
HCID10219638

di-tert-butylcarbonate

C9H18O3

PRODUCTS

生成物

1
结构：Cc1c(O)cccc1NC(=O)OC(C)(C)C
HCID22033487

未命名化合物

收率 69%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

3-Amino-2-methylphenol (2.0 g; 16 mmol) and di-t-butylcarbonate were dissolved in THF (20 mL) and refluxed overnight. Evaporation of the solvent followed by flash chromatography (SiO2; EtOAc 5–30% in isohexane) afforded 2.48 g (69%) of the sub-title compound.

WORKUP

后处理

  1. temperaturerefluxed overnight
  2. customEvaporation of the solvent