反应详情

3-Aminothiophenol (0.87 g; 7.0 mmol), 4-toluenesulfonic acid-2-(4-cyanophenyl)ethyl ester (2.0 g; 6.6 mmol; from step (i) above) and K2CO3 (1 g) were stirred in a mixture of EtOH (10 mL) and CH2Cl2 for 4 hours. Addition of ether, washing with brine and 2M aqueous NaOH, drying (MgSO4), evaporation of the solvent and flash chromatography (SiO2; Et2O:hexane (1:1)) afforded 0.82 g (49%) of the sub-title compound.

1. washwashing with brine and 2M aqueous NaOH
2. customdrying
3. custom(MgSO4), evaporation of the solvent and flash chromatography (SiO2; Et2O:hexane (1:1))