Water → 2-Chloro-4-fluorobenzenesulfonic acid, 3-[2-(4-cyanophenyl)ethoxy]-5-chlorophenyl ester

HRID 1791873ノート

反応式

HRID 1791873 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9](Cl)(=[O:11])=[O:10].[Cl:13][C:14]1[CH:15]=[C:16]([OH:31])[CH:17]=[C:18]([O:20][CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]#[N:30])=[CH:25][CH:24]=2)[CH:19]=1.O>N1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9]([O:31][C:16]1[CH:15]=[C:14]([Cl:13])[CH:19]=[C:18]([O:20][CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]#[N:30])=[CH:25][CH:24]=2)[CH:17]=1)(=[O:11])=[O:10]

参加物

5

反応物 3

HCID 962WaterHCID 5228462-Chloro-4-fluorobenzene-1-sulfonyl chlorideHCID 220335343-Chloro-5-[2-(4-cyanophenyl)ethoxy]phenol

生成物 1

HCID 572825492-Chloro-4-fluorobenzenesulfonic acid, 3-[2-(4-cyanophenyl)ethoxy]-5-chlorophenyl ester収率 72.1%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

2-Chloro-4-fluorobenzenesulfonyl chloride (1.16 g; 5.0 mmol) was added to a cold solution (ice:water temperature) of 3-chloro-5-[2-(4-cyanophenyl)ethoxy]phenol (0.689 g; 2.5 mmol; from step (ii) above) in pyridine (8 mL). The temperature was allowed to rise (slowly) to ambient overnight. The mixture was re-cooled (ice:water temperature) and ice was added to the reaction flask. After stirring for 4 hours, the pyridine was removed in vacuo. CH2Cl2 was then added and the organic layer was washed with aqueous KHSO4 and water. Drying (MgSO4), evaporation of the solvent and purification by flash chromatography (SiO2; CH2Cl2) afforded 0.84 g (72%) of the sub-title compound.

後処理

  1. customto ambient overnight
  2. additionwas added to the reaction flask
  3. customthe pyridine was removed in vacuo
  4. additionCH2Cl2 was then added
  5. washthe organic layer was washed with aqueous KHSO4 and water
  6. customDrying
  7. custom(MgSO4), evaporation of the solvent and purification by flash chromatography (SiO2; CH2Cl2)

出典と根拠

ORDレコード
ord-fc3a3854b6594410bd7d1f6b1836866b
出典データセット
uspto-grants-2006_07
特許番号
US07074820B2

反応ノート

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