Water → HCID 69111134, compound

HRID 1791884Notes

Reaction equation

HRID 1791884 reaction equation
[N+:1]([C:4]1[CH:15]=[C:8]2[C:9]([O:11][C:12](=O)[NH:13][C:7]2=[CH:6][CH:5]=1)=[O:10])([O-:3])=[O:2].C[O-].[Na+].[CH:19]1([C:22](Cl)=[O:23])[CH2:21][CH2:20]1.O>CO>[CH3:12][O:11][C:9](=[O:10])[C:8]1[CH:15]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[CH:6][C:7]=1[NH:13][C:22]([CH:19]1[CH2:21][CH2:20]1)=[O:23]

Participants

6

Reactant 4

HCID 962WaterHCID 208212H-3,1-Benzoxazine-2,4(1H)-dione, 6-nitro-HCID 77637Cyclopropanecarbonyl chlorideHCID 10942334Sodium Methoxide

Product 1

HCID 69111134HCID 69111134, compoundYield 0.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

5-nitroisatoic anhydride (20.8 g, 0.1 mol) ) was heated to reflux with sodium methoxide (0.5 g, 0.01 mol) in methanol (600 mL). After 1 h, the solvent was evaporated under vacuum and the residue dissolved in 1,2-dichloroethane (400 mL), washed with cold water and dried over MgSO4. Cyclopropanecarbonyl chloride (20.9 g, 0.2 mol) was added to the solution and then heated at 80° C. for 4.5 h. The mixture was allowed to cool and water (200 mL) was added under vigorous stirring. After 0.5 h, the stirring was interrupted and the phases separated, the C2H4Cl2 layer washed with sodium bicarbonate solution and dried over MgSO4. Evaporation of the solvent afforded 2-(cyclopropanecarbonyl-amino)-5-nitro-benzoic acid methyl ester (21.7 g, 0.082 mmol). This material was dissolved in methanol (500 mL) and 10% Pd/C (2.2 g) was added. The flask was then flushed with H2 and stirred at room temperature and at 1 atm. After 5 h reduction, the catalyst was removed by filtration through Celite. The catalyst was carefully washed and the combined filtrate evaporated to dryness to give the pure title compound as a grey solid (18.0 g, 0.077 mol).

Workup

  1. customthe solvent was evaporated under vacuum
  2. dissolutionthe residue dissolved in 1,2-dichloroethane (400 mL)
  3. washwashed with cold water
  4. dry with materialdried over MgSO4
  5. temperatureto cool
  6. waitAfter 0.5 h
  7. customthe phases separated
  8. washthe C2H4Cl2 layer washed with sodium bicarbonate solution
  9. dry with materialdried over MgSO4
  10. customEvaporation of the solvent

Sources & evidence

ORD record
ord-215d2c327f6d4a1a9bc8cd835e984599
Source dataset
uspto-grants-2006_07
Patent number
US07074831B2

Reaction notes

Loading…