Piperazine → 6-(Piperazin-1-yl)pyridine-3-carboxamide

HRID 1791920Notes

Reaction equation

Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][N:3]=1.[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>>[C:6]([C:5]1[CH:9]=[CH:10][C:2]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[N:3][CH:4]=1)(=[O:7])[NH2:8]

Participants

Reactant 2

HCID 4837Piperazine

HCID 804566-Chloronicotinamide

Product 1

HCID 220289886-(Piperazin-1-yl)pyridine-3-carboxamideYield 6.2%

Procedure

Using 6-chloronicotinamide (5.00 g) and piperazine (27.6 g), and by reaction in the same manner as in Example 196 (1) at 100° C., 1-(5-carbamoyl-2-pyridyl)piperazine (0.41 g) was obtained as a yellow powder.

Sources & evidence

ORD record: ord-4d07e9a838ac401f84a0d0ffd1310bb7
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074794B2

Reaction notes

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