HCID 23081912, compound → HCID 22029749, compound

HRID 1792031Notes

Reaction equation

HRID 1792031 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[Cl:29])[C:21]3[C:20](=[O:30])[N:19]([CH3:31])[C:18](=[O:32])[N:17]([CH3:33])[C:16]=3[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[Cl:29][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[N:22]1[C:21]2[C:20](=[O:30])[N:19]([CH3:31])[C:18](=[O:32])[N:17]([CH3:33])[C:16]=2[N:15]=[C:14]1[N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

3

Reactant 1

HCID 23081912HCID 23081912, compound

Product 1

HCID 22029749HCID 22029749, compoundYield 135.4%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

4-[7-(2-Chlorophenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]piperazine-1-carboxylic acid tert-butyl ester (102 mg) was dissolved in trifluoroacetic acid (5 ml), and the solution was stirred at room temperature for 30 minutes. After the solvent was removed, the residue was purified by column chromatography using NH-silica gel to obtain 109 mg of the title compound from a fraction eluted with ethyl acetate-methanol (9:1).

Workup

  1. customAfter the solvent was removed
  2. customthe residue was purified by column chromatography

Sources & evidence

ORD record
ord-d4c8e39431ef46498ae1c005321f4aff
Source dataset
uspto-grants-2006_07
Patent number
US07074798B2

Reaction notes

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